SCI

1 May 2024

The case for therapeutic overactivation of oncogenic signaling as a potential cancer treatment strategy

(Cancer Cell; if=50.3)

  • Dias MH, Papagianni C, Bernards R.

  • Correspondence: r.bernards@nki.nl 

Most targeted cancer drugs inhibit the oncogenic signals to which cancer cells are addicted. We discuss here a counterintuitive approach to cancer therapy, which consists of deliberate overactivation of the oncogenic signals to overload the stress responses of cancer cells. We discuss why such overactivation of oncogenic signaling, combined with perturbation of the stress response pathways, can be potentially effective in killing cancer cells, aiming to inspire further discussion and consideration.

大多数癌症靶向药物抑制癌症细胞所依赖的致癌信号。我们在这里讨论了一种违反直觉的癌症治疗方法，该方法包括故意过度激活致癌信号，以使癌症细胞的应激反应过载。我们讨论了为什么这种致癌信号的过度激活，再加上应激反应途径的扰动，可以潜在地有效杀死癌症细胞，旨在激发进一步的讨论和思考。