SCI

18 May 2024

Tumor cell-intrinsic epigenetic SETpoint of cancer-associated fibroblasts

（Cancer Cell; IF：50.3）

  • Chen X, Huang H: Tumor cell-intrinsic epigenetic SETpoint of cancer-associated fibroblasts. Cancer Cell 2024.

  • Correspondence: huocong.huang@utsouthwestern.edu

Cancer-associated fibroblasts (CAFs) exhibit spatial and functional diversity. Here, Niu et al. unveil SETD2’s function in lipid metabolism and CAF heterogeneity in pancreatic ductal adenocarcinoma. SETD2 deficiency boosts oxidative phosphorylation activity, prompting lipid-laden CAF formation through BMP2 signaling, offering promising therapeutic avenues in personalized cancer treatment.

肿瘤相关成纤维细胞(CAFs)具有空间和功能多样性。在这里，Niu等揭示了SETD2在胰腺导管腺癌的脂质代谢和CAF异质性中的作用。SETD2缺陷增强氧化磷酸化活性，通过BMP2信号通路促进脂质负载CAF形成，为个性化癌症治疗提供了有前景的治疗途径。