SCI
7 October 2024
CAF-induced physical constraints controlling T cell state and localization in solid tumours
(IF: Nat Rev Cancer., 72.5)
Arpinati L, Carradori G, Scherz-Shouval R. CAF-induced physical constraints controlling T cell state and localization in solid tumours. Nat Rev Cancer. 2024 Oct;24(10):676-693.
Correspondence: ruth.shouval@ weizmann.ac.il
Solid tumours comprise cancer cells that engage in continuous interactions with non-malignant cells and with acellular components, forming the tumour microenvironment (TME). The TME has crucial and diverse roles in tumour progression and metastasis, and substantial efforts have been dedicated into understanding the functions of different cell types within the TME. These efforts highlighted the importance of non-cell autonomous signalling in cancer, mediating interactions between the cancer cells, the immune microenvironment and the non-immune stroma. Much of this non-cell-autonomous signalling is mediated through acellular components of the TME, known as the extracellular matrix (ECM), and controlled by the cells that secrete and remodel the ECM - the cancer-associated fibroblasts (CAFs). In this Review, we delve into the complex crosstalk among cancer cells, CAFs and immune cells, highlighting the effects of CAF-induced ECM remodelling on T cell functions and offering insights into the potential of targeting ECM components to improve cancer therapies.
实体肿瘤由癌细胞组成，这些癌细胞与非恶性细胞以及非细胞成分持续相互作用，形成肿瘤微环境（TME）。TME在肿瘤进展和转移中扮演着至关重要且多样的角色，人们已经投入了大量精力去理解TME中不同细胞类型的功能。这些努力突显了非细胞自主信号在癌症中的重要性，即介导癌细胞、免疫微环境和非免疫基质之间的相互作用。这种非细胞自主信号的大部分是通过TME的非细胞成分介导的，即细胞外基质（ECM），并由分泌和重塑ECM的细胞——癌症相关纤维母细胞（CAFs）控制。在本综述中，我们深入探讨了癌细胞、CAFs和免疫细胞之间的复杂串扰，强调了CAF诱导的ECM重塑对T细胞功能的影响，并提供了针对ECM组分以改善癌症治疗的潜在可能性的见解。
