《柳叶刀》(The Lancet)最新发表的两项早期临床试验显示,新型药物Amycretin在体重管理和血糖控制方面展现出良好前景。作为一种单分子GLP-1和胰岛淀粉素受体双激动剂,Amycretin通过同时作用于人体的GLP-1受体与胰岛淀粉素受体,实现血糖调控与食欲控制作用。研究人员指出,相较于单一受体靶向药物,这一双重激动剂在超重及肥胖问题管理方面更具优势。识别文中二维码或点击文末阅读原文,查阅原文。


《柳叶刀》(The Lancet最新发表的两项早期临床试验显示,新型体重管理药物Amycretin展现出良好前景。Amycretin通过同时作用于人体的GLP-1受体与胰岛淀粉素受体,实现血糖调控与食欲控制作用。研究人员指出,相较于单一受体靶向药物,这一双重激动剂在超重及肥胖问题管理方面更具优势


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一项1b/2a期临床试验对125名超重或肥胖成人进行了每周一次Amycretin皮下注射(皮肤下层、肌肉上层)的安全性及耐受性测试。接受最高剂量(达60毫克)组受试者在36周疗程后报告体重降幅可达24.3%。试验观察到较频繁的胃肠道不良反应(包括恶心、呕吐),但多数为轻至中度,且通常随治疗结束自行缓解。Amycretin同时展现出改善血糖水平的效果,但需进行进一步的临床试验以证实其在糖尿病管理领域的作用。


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另一项1期临床试验对144名受试者进行了为期12周的每日口服给药Amycretin研究。这项首次人体试验证实了Amycretin的安全性及耐受性,主要不良反应为轻至中度胃肠道症状,包括食欲减退、恶心以及呕吐。口服最高剂量(每日100毫克)组受试者在12周后平均体重下降13.1%,表明口服剂型Amycretin可成为具有前景的体重管理药物


综合两项研究结果,无论是周注射剂型还是日口服剂型,Amycretin均展现出治疗超重、肥胖及2型糖尿病的前景,但仍需更大规模研究验证以上试验结果


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在两篇文章的相关评论中,Professor Tricia Tan与Dr Bernard Khoo(均未参与上述研究)强调,肥胖管理除了关注减重效果之外,更需评估治疗手段对降低心血管疾病等肥胖相关疾病风险的作用END


Declaration of interests


The phase 1 trial was funded by Novo Nordisk A/S.

AG, AH, SG, JBH, KK, TK, SBP, ST, and AV are employees of and shareholders in Novo Nordisk A/S. CK is an employee of ICON (contract research organisation). ICON received funding from Novo Nordisk A/S for conducting the clinical study described in this manuscript, for which CK was the principal investigator.


The 1b/2a trail was funded by Novo Nordisk.

KD, ST, SD, RDdV, AF, AG, AH, SBP, AV, and KA are employees of and shareholders in Novo Nordisk. CK is an employee of ICON, which received funding from Novo Nordisk for conducting the clinical study described in this manuscript, for which CK was the principal investigator. AMJ reports conduct of multicentre trials with Amgen, Boehringer Ingelheim, Eli Lilly, Novo Nordisk, and Rhythm Pharmaceuticals; serving on scientific advisory boards for Amgen, AstraZeneca, Boehringer Ingelheim, Biohaven, Eli Lilly, Intellihealth, Metsera, Novo Nordisk, Pfizer, Regeneron Pharmaceuticals, Roche, Scholar Rock, State 4 Therapeutics, Structure Therapeutics, Syntis Bio, Terns Pharmaceuticals, WeightWatchers, and Zealand Pharmaceuticals; institutional grant funding from the US National Institutes of Health (National Institute of Diabetes and Digestive and Kidney Diseases); travel support from Amgen, Novo Nordisk, Boehringer Ingelheim, Eli Lilly, and WeightWatchers; participation on a data safety monitoring board for the University of Minnesota (two studies); serving on the governance board for The Obesity Society, the Obesity Algorithm Task Force of the American Association of Clinical Endocrinologists; being an Associate Editor for the American Diabetes Association and Diabetes Care; holding stock or stock options with Intellihealth, State 4 Therapeutics, and Syntis Bio; and receipt of equipment, materials, drugs, medical writing, gifts, or other services from Novo Nordisk.



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中文翻译仅供参考,所有内容以论文原文为准

1b/2a期试验 https://doi.org/10.1016/S0140-6736(25)01185-7

1期试验 https://doi.org/10.1016/S0140-6736(25)01176-6

评论 https://doi.org/10.1016/S0140-6736(25)01250-4


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