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过去二十年间,髋关节置换术所用材料的改进显著降低了磨损,可能延长了植入物的使用寿命。《柳叶刀》(The Lancet)发表一项系统性综述与meta分析,旨在评估现代全髋关节置换术及其承重材料的生存率。研究发现,约93%的现代髋关节置换术可持续使用至少20年,进一步建模显示,约92%的现代髋关节置换术可保持良好功能至少30年。结果表明,承重界面技术的进步显著提升了全髋关节置换的长期耐用性,并可能对患者咨询、医疗规划及器械监管产生影响。识别文中二维码或点击文末“阅读原文”,查阅原文。

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《柳叶刀》(The Lancet发表的一项研究表明,现代髋关节置换术[1]持续使用至少25年的可能性几乎是传统髋关节置换术[2]的两倍。这是一项系统性综述与meta分析,研究者使用高级建模技术,估计约92%的现代髋关节置换术有望持续使用至少25年。与早期关于传统髋关节置换术的研究相比,这是一个显著的进步。早期研究表明,仅约58%的植入物能够持续使用25年。


髋关节置换术是一项非常成功的手术,帮助全球数百万患者恢复行动能力并提高生活质量。随着越来越多的年轻患者接受该手术,以及人均寿命延长,了解这些植入物的使用寿命变得愈发重要。过去二十年间,髋关节置换术所用材料的改进显著降低了磨损,可能延长了植入物的使用寿命。然而,至今仍缺乏大规模研究来评估现代髋关节置换术的实际使用寿命。最近一次的重要评估来自《柳叶刀》于2019年发表的一项研究[3],其结果显示仅约58%的植入物在25年后仍能正常工作,但该研究纳入了已不再使用的旧式材料,这些材料更易发生磨损或断裂。

本研究纳入了来自8个国家关节登记处的数据,涵盖近190万例髋关节置换术,涉及5000余名患者的临床研究。分析发现,约93%的现代髋关节置换术可持续使用至少20年,进一步建模显示,约92%的现代髋关节置换术可保持良好功能至少30年。作者强调,尽管这些结果在群体层面令人欣慰,但并不能预测个体患者的髋关节置换术的具体使用寿命,因为患者年龄、整体健康状况、骨骼质量以及所使用的手术技术等因素都会影响最终效果。

研究结果表明,现代髋关节置换术使用寿命显著延长,有助于医生为患者提供更明确的预期,并为未来医疗保健规划提供依据。对医院和医疗卫生服务机构而言,这意味着需要重复手术的患者将减少,使专科团队能够专注于复杂病例,并帮助更多患者获得首次髋关节置换术的机会。


现代全髋关节置换术30年生存率:
全球关节登记数据的系统综述、meta分析及外推研究

背景
全髋关节置换术是一项成功的手术,旨在帮助全球数百万患者恢复功能并提高生活质量。了解全髋关节置换术的预期使用寿命,对于患者、外科医生及医疗卫生机构进行规划与资源配置至关重要。过去二十年间,现代承重界面在全髋关节置换中的应用显著改变了植入物的磨损情况,并可能延长了其使用寿命。然而,至今仍缺乏大规模研究来评估这些植入物的生存率。本研究旨在评估现代全髋关节置换术及其承重材料的生存率。

方法
本研究仅专注于评估现代承重界面:高交联聚乙烯对金属或第三代、第四代陶瓷头,以及陶瓷对陶瓷初次全髋关节置换术在成年患者中的应用。研究者们系统检索了MEDLINE和Embase数据库,检索时间从建库至2024年6月13日,纳入报告了至少10年生存率的研究,无论何种固定方式或手术入路。随后进行了一项meta分析,整合8个国家关节登记处的数据,评估不同承重界面组合的全因翻修率。我们运用登记数据中的多变量随机效应模型,对提取的数据进行推算,以估算30年生存率。主要结局指标为髋关节置换术的生存率,定义为初次全髋关节置换至首次全因翻修的时间,以特定时间点未翻修植入物的百分比表示。本研究已在PROSPERO注册(CRD42024572518)。

结果
本研究共纳入29项临床研究(n=5,203)和8个国家关节登记处(n=1,899,034)中的1,904,237例全髋关节置换术。对纳入研究的合并分析显示,在随机效应模型下,植入物全因生存率为0.97(0.96–0.98)。基于关节登记数据的20年生存率估计值为93.6%(95% CI 92.3–94.7)。外推这些数据,预测25年生存率为92.8%(91.2–94.2),30年生存率为92.1%(90.1–93.7)

解释
现代全髋关节置换术30年生存率估计为92%,这表明承重界面技术的进步显著提升了全髋关节置换的长期耐用性,并可能对患者咨询、医疗规划及器械监管产生影响。END

Funding

None

Declaration of interests

EB reports receiving payment or honoraria for lectures, presentations, speakers’ bureaus, manuscript writing, or educational events from Stryker; support for attending meetings and travel from DePuy; leadership or fiduciary roles with the Canadian Joint Replacement Registry (Chair, Advisory Committee); the International Society of Arthroplasty Registries (President); and the Canadian Arthroplasty Society (President); and institutional educational support from Smith & Nephew and DePuy. DC reports royalties or licences from Smith & Nephew for revision component design; holding leadership or fiduciary roles as Chair of the Glenelg Hospital Medical Advisory Committee and as a Review Panel Member for the National Joint Replacement Registry; and holding stock or stock options in Austofix Orthopaedics. ONF reports payment or honoraria for lectures, presentations, speakers’ bureaus, manuscript writing, or educational events from Ortomedic AS (lectures in knee replacement surgery) and Heraeus Medical (lectures in cementation techniques in knee replacement surgery). NH reports institutional grants or contracts from the Swedish Research Council (VR 2019-00436; VR 2021-00980), Stiftelsen Promobilia, and Skobranschens utvecklingsfond; royalties or licences with Waldemar Link (licence agreement, no remuneration); consulting fees from DePuy; payment or honoraria for lectures or educational events from Waldemar Link, Zimmer Biomet, and Heraeus Medical; participation as a contributor on the STOP Leg Clots Trial Data Safety Monitoring Board or advisory activities; and holding unpaid leadership or fiduciary roles as Scientific Advisor to the Swedish National Board of Health and Welfare, Board Member of the Swedish Arthroplasty Register, Chair of the Nordic Association of Arthroplasty Registers, and Chair of Biobank Sweden under the Swedish Research Council infrastructure. EL reports support from the National Joint Registry (NJR) through employment and their research unit and from the NJR committee to produce annual reports and research outputs; grants or contracts from CeramTec Group, National Institute for Health and Care Research (NIHR), and Tommy's Charity, with funding paid to the author's university to support employment of a research unit; and participating as a Data Monitoring and Ethics Committee member for an NIHR-funded study (2024–26). SO reports institutional grants or contracts from the Novo Nordisk Foundation and the Independent Research Fund for research funding; payment or honoraria from Heraeus (paid to the institution for lectures and course moderation); and holding leadership or fiduciary roles as a Member of the Executive Committee and Board of the Nordic Orthopaedic Federation (unpaid) and as Editor-in-Chief of Acta Orthopaedica (personal remuneration). MR reports institutional grants or contracts from Stryker (supporting the Bone and Joint Infection Registry) and Microsoft (machine learning-based risk prediction support through the Microsoft Founders Programme); consulting fees from Heraeus Medical (for unrelated medical devices, paid to a company partly owned by the author) and Pharmacosmos (advisory board); payment or honoraria for lectures or educational activities from Zimmer Biomet, Heraeus Medical, Stryker, Pharmacosmos, Ethicon, Amotio, and Adler; an unpaid fiduciary role as Trustee of the charity OR-UK; and holding stock or stock options in OpenPredictor Holdings, Open Predictor Clinical Intelligence, and Neuranics. OR reports consulting fees from LINK Sweden, AstraZeneca, and Johnson & Johnson; payment or honoraria for educational consulting from LINK Sweden (fees paid to the author); and holding a leadership or fiduciary role as Director of the Swedish Arthroplasty Registry, with payments made to the author's employer. CV reports receiving support for attending meetings and/or travel from Stryker, with payments made to the institution. MW reports support from the NIHR Bristol Biomedical Research Centre, with institutional funding supporting part of the author's time; grants or contracts from NIHR, and Health-care Quality Improvement Partnership as principal investigator, co-principal investigator, or co-applicant on multiple funded studies, with payments made to the institution; royalties or licences with Taylor & Francis for two orthopaedic textbooks; payment or honoraria for educational activities from Heraeus, with payments made to the institution; participating on Trial Steering Committees and Data Monitoring Committees for NIHR-funded studies; unpaid leadership or fiduciary roles with the British Hip Society (Chair, Research Committee) and the British Orthopaedic Association (member, Research Committee); and a leadership role with the NIHR Clinical Research Network, with institutional support provided. All other authors declare no competing interests.



References

[1] Modern hip replacements use more durable materials such as highly cross-linked polyethylene (XLPE) and newer types of ceramics, which became the standard treatment worldwide by 2008

[2] Older hip replacements used ultra-high-molecular-weight polyethylene (UHMWPE) for the hip socket or liner, which can wear and trigger inflammation, leading to bone loss and the implant loosening
[3] https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)31665-9/fulltext


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题图 Copyright: SCIEPRO/SCIENCE PHOTO LIBRARY/Getty Images

中文翻译仅供参考,所有内容以英文原文为准。

DOI: 10.1016/S0140-6736(25)02305-0


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